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What is NMIBC?

What is Non-Muscle Invasive Bladder Cancer (NMIBC)?

The bladder is the organ that holds urine and consists of muscles that contract to push urine out through the urethra when you urinate. These muscles are protected from the center of the bladder, as they are positioned underneath the bladder lining and layers of tissue. Non-muscle invasive bladder cancer (NMIBC) happens when cancer cells grow in this tissue area that lines the center of the bladder, but the cancer does not reach any layers of bladder muscle.

You may qualify for the LEGEND study if you have one of the following American Urologic Association/Society of Urologic Oncology categories based on AUA / SUO definitions of NMIBC:

bladder cancer

Usually, the first step to treating bladder cancer involves surgery to remove the tumor, followed by bacillus Calmette-Guerin (BCG) therapy to reduce the risk of the cancer coming back. BCG therapy does not work for everyone, and if the cancer comes back, bladder removal is often recommended. The LEGEND study is designed to find out if the study drug could be a safe and effective option that would provide people at this point in their bladder cancer journey an alternative treatment to hopefully treat the reoccurring cancer cells and avoid the removal of their bladder. 

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